Liquid chromatography mass spectrometry (LC-MS) is an analytical method that combines the advantages from both liquid chromatography and mass spectrometry. In combining these two techniques, identification of different substances within a test sample is accomplished. The field of application for the LC-MS is wide-ranging, for example, clinical analysis and analysis of food, environment and pharmaceutical residues.

Application requirements

  • Different vacuum pressures in different stages
  • High reliability
  • High pumping speed of backing pump

How does it work?
A LC/MS is a combination between a liquid chromatograph (LC) and a mass spectrometer (MS). The liquid chromatograph is used to unstitch the researching mixture and the mass spectrometer to identify the individual components. Electrospray ionization (ESI) or chemical ionization at atmospheric pressure are often used as ionization techniques because they can be directly coupled with the LC. Through the coupling of the two methods the result will be a mass spectrum for every point of the chromatograph, which identify and characterize possible contaminants.

Product portfolio
Due to the different vacuum pressures necessary in the different mass spectrometry stages, the turbopump is the core of the vacuum system. Therefore, Pfeiffer Vacuum manufactures a customized SplitFlow turbopump to evacuate different vacuum stages with only one pump. To reach the essential pressure range, a backing pump is also necessary. There are various options possible such as dry backing pumps, like diaphragm pumps, or Roots pumps as well as rotary vane pumps. To realize your working pressure, Pfeiffer Vacuum offers a wide range of gauges. With the RS-485 interface, most of the products from Pfeiffer Vacuum can communicate with each other, resulting in one controller for your entire vacuum system.

Main products

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